Proteasome 20S alpha 7 antibody (70R-12603)

Affinity purified Rabbit polyclonal Proteasome 20S alpha 7 antibody

Synonyms Polyclonal Proteasome 20S alpha 7 antibody, Anti-Proteasome 20S alpha 7 antibody, HSPC antibody, proteasome subunit XAPC7 antibody, MGC3755 antibody, RC6-1 antibody, PSMA7 antibody, C6 antibody, proteasome subunit alpha type-7 antibody, XAPC7 antibody, Proteasome S alpha 7 20, proteasome subunit alpha 4 antibody, Proteasome S alpha 7-20, Proteasome S alpha 7-20 antibody, Proteasome 20S alpha 7, Proteasome S alpha 7 20 antibody
Cross Reactivity Human, Mouse
Applications IHC-P, WB
Immunogen Proteasome 20S alpha 7 antibody was raised in rabbit using a recombinant fragment corresponding to a region within amino acids 10 and 247 of Proteasome 20S alpha 7

Images

Western blot analysis using Proteasome 20S alpha 7 antibody (70R-12603)

Western blot analysis of 50 ug of whole cell lysate (A: Mouse brain) using a 12 % SDS PAGE gel and Proteasome 20S alpha 7 antibody at a dilution of 1:1000

Specifications

Host Rabbit
Isotype IgG
Method of Purification Proteasome 20S alpha 7 antibody was purified by antigen-affinity chromatography
Molecular Weight 28 kDa
Form & Buffer Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative.
Concentration 0.32 mg/ml

Usage & Assay Information

Usage Recommendations IHC-P: 1:100-1:500, WB: 1:500-1:3000

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. This particular subunit has been shown to interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. In addition, this subunit is involved in regulating hepatitis virus C internal ribosome entry site (IRES) activity, an activity essential for viral replication.

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Images

  • <div><font face=Calibri size=2>Western blot analysis using Proteasome 20S alpha 7 antibody (70R-12603)</font></div>     | Western blot analysis of 50 ug of whole cell lysate (A: Mouse brain) using a 12 % SDS PAGE gel and Proteasome 20S alpha 7 antibody at a dilution of 1:1000
  • <div><font face=Calibri size=2>Western blot analysis using Proteasome 20S alpha 7 antibody (70R-12603)</font></div>     | Western blot analysis of 30 ug of whole cell lysate (A: A431; B: H1299; C: Hela; D: Hep G2) using a 12 % SDS PAGE gel and Proteasome 20S alpha 7 antibody at a dilution of 1:1000
  • <div><font face=Calibri size=2>Immunohistochemical staining using Proteasome 20S alpha 7 antibody (70R-12603)</font></div>     | Immunohistochemical staining of paraffin-embedded CL1-5 xenograft using Proteasome 20S alpha 7 antibody at a dilution of 1:100

Availability: In stock

Price: €323.11
Size: 100 ul
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