Protein A (30-AP76)
Immunoglobulin-binding bacterial Protein A solution
Overview
Overview
| Species | S.aureus |
|---|---|
| Protein Type | Native |
| Applications | User optimized |
Specifications
| Source | Staphylococcus aureus |
|---|---|
| Grade & Purity | > 95% pure |
| Form & Buffer | Supplied as a lyophilized powder. |
Storage & Safety
| Storage | Aliquot and store at -20 deg C. Avoid repeated Freeze/Thaw cycles |
|---|
General Information
| Biological Significance | Protein A is a 40-60 kDa MSCRAMM surface protein originally found in the cell wall of the bacteria Staphylococcus aureus. It is encoded by the spa gene and its regulation is controlled by DNA topology, cellular osmolarity, and a two-component system called ArlS-ArlR. It has found use in biochemical research because of its ability to bind immunoglobulins. It binds proteins from many of mammalian species, most notably IgGs. It binds with the Fc region of immunoglobulins through interaction with the heavy chain. The result of this type of interaction is that, in serum, the bacteria will bind IgG molecules in the wrong orientation (in relation to normal antibody function) on their surface which disrupts opsonization and phagocytosis. |
|---|
Reviews
You need to be logged in to write a review. Please login here
Sorry there are currently no reviews for this product