Prothrombin protein (30C-CP3048U)
Purified native Human Prothrombin protein
Overview
Overview
| Species | Human |
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| Protein Type | Native |
| Applications | User optimized |
Specifications
| Source | Human serum/plasma |
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| Grade & Purity | > 98% pure |
| Molecular Weight | 72 kDa |
| Form & Buffer | Supplied as a liquid with 50% Glycerol/H2O (vol/vol). |
| Concentration | Batch dependent - please inquire should you have specific requirements |
Usage & Assay Information
| Bioactivity | 9.7 units/mg protein - One unit of activity is equivalent to the Prothrombin activity in one milliliter of human normal plasma. |
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Storage & Safety
| Storage | Aliquot and store at -20 deg C. Avoid repeated Freeze/Thaw cycles |
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| Biohazard Information | Donor samples were tested and found to be negative for anti-HIV-1/2, HIV-1 antigen(s), HBsAg, STS, anti-HCV, anti-HBcore and anti-HTLV I & II. Nonetheless caution should be used when handling this material as there is a margin of error in all tests. |
General Information
| Biological Significance | Prothrombin is a vitamin K-dependent plasma protein which is synthesized in the liver. Prior to secretion into plasma, prothrombin undergoes post-translational modification by a vitamin K-dependent carboxylase which converts ten specific glutamic acid residues to gamma-carboxyglutamic acid (gla). The ten gla residues are located within the first 40 amino acids of the mature protein and contribute to the ability of prothrombin to bind to negatively charged phospholipid membranes. |
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