PSA-ACT protein (30-1946)
Partically pure human PSA-ACT antigen
Overview
Overview
| Synonyms | PSA-ACT complex antigen, PSA-ACT antigen, Native PSA-ACT protein, Prostate Specific Antigen/1-antichymotrypsin complex protein |
|---|---|
| Species | Human |
| Protein Type | Native |
Specifications
| Source | Human seminal and blood plasma |
|---|---|
| Grade & Purity | > 40% pure |
| Molecular Weight | 88 kDa |
| Form & Buffer | Supplied as liquid in 50 mM sodium acetate, 0.15 M NaCl, pH 5.6, with 0.09% sodium azide, 20% glycerol and 0.3% Proclin-300 |
| Concentration | > 0.6 mg/ml |
Storage & Safety
| Storage | Ships on dry ice. Upon receipt store at -20°C. Avoid repeated freeze thaw cycles. |
|---|
General Information
| Biological Significance | Prostate Specific Antigen (PSA), a glycoprotein of the glandular kallikrein family, is a serine protease with hymotrypsin-like enzymatic activity, is monitored as increased levels can indicate prostatic neoplasia. PSA released into circulation is present as unbound, free PSA (fPSA) or bound to serum protease inhibitors, such as a1-antichymotrypsin (ACT) and a2-macroglobulin (A2M). |
|---|---|
| Implications in Disease | Serum levels of PSA-ACT complex are reportedly higher in patients with prostate cancer than in those with BPH. As such, measuring the ratio of PSA-ACT to fPSA in patient samples is proving valuable in the differential diagnosis os prostate cancer. |
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