PSIP fragment protein (His tag only) (80-1384HIS)

Purified recombinant PSIP (DSF70) fragment protein (His tag only)

Synonyms Dense Fine Speckle Protein fragment protein, DSF70 fragment protein, PSIP protein, PC4 And SFRS1 Interacting Protein 1 fragment, PSIP1 fragment protein
Species Human
Protein Type Recombinant

Images

Coomassie blue stained SDS-PAGE of PSIP fragment protein (His tag) (80-1384)

Specifications

Residues 349-455 aa N-terminal His tag
Expression System Baculovirus
Grade & Purity > 90% pure
Method of Purification Purified using proprietary chromatographic techniques
Molecular Weight 16 kDa
Tag/Conjugate His tag
Form & Buffer Supplied in PBS with 10% glycerol, 2mM DTT, 0.02% SDSand 1mM EDTA

Storage & Safety

Storage Ships on dry ice. Aliquot and store at -70 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance PSIP is a transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis.
Expression SIP is highly expressed in the presence of the menin/MLL protein complex. Tissue and Cell Localization: PSIP1 is found mainly in the nucleus and remains chromatin-associated throughout the cell cycle.
Implications in Disease A chromosomal aberration involving PSIP is associated with pediatric acute myeloid leukemia (AML). Defects in PSIP1 expression have also been linked with dysembryoplastic neuroepithelial tumors.
Post-Translational Modifications PSIP is citrullinated by PADI4. Ubiquitination occurs at Lys6, Lys75, Lys364, Lys407, Lys415, Lys422, Lys424 and Lys442. PSIP1 is phosphorylated upon DNA damage, probably by ATM or ATR.
Database Links Entrez Gene: 11168 Human, Omim: 603620 Human, SwissProt: O75475 Human, Unigene: 726445 Human

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Images

  • Coomassie blue stained SDS-PAGE of PSIP fragment protein (His tag) (80-1384)

Availability: In stock

Price: €663.39
Size: 1 mg
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