PSIP1 protein (His tag) (80-1381)
Purified recombinant PSIP1 (DSF70) protein (His tag)
Overview
Overview
| Synonyms | Dense Fine Speckles 70 protein, DSF70 protein, PSIP protein, PC4 And SFRS1 Interacting Protein 1, LEDGF protein |
|---|---|
| Species | Human |
| Protein Type | Recombinant |
Specifications
| Residues | 1-530 aa |
|---|---|
| Expression System | Baculovirus |
| Grade & Purity | > 90% pure |
| Method of Purification | Purified using proprietary chromatographic techniques |
| Molecular Weight | 64 kDa |
| Tag/Conjugate | His tag |
| Form & Buffer | Supplied in 50mM Na2PO4, pH 7.0, 150mM NaCl, 10% glycerol, 2mM DTT, 1mM EDTA |
Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -70 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
|---|
General Information
| Biological Significance | PSIP1 is involved in particular in lens epithelial cell gene regulation and stress responses. |
|---|---|
| Expression | PSIP1 is highly expressed in the presence of the menin/MLL protein complex. PSIP1 is found mainly in the nucleus and remains chromatin-associated throughout the cell cycle. |
| Implications in Disease | A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML). Defects in PSIP1 expression have also been linked with dysembryoplastic neuroepithelial tumors. |
| Sequence Information | PSIP1 is composed of 530 amino acids with a molecular weight of 60103 Da. There is a PC4 and SFRS1-interacting protein at position 1 – 530 and a nuclear localization signal motif at position 146 – 156. |
| Post-Translational Modifications | PSIP1 is citrullinated by PADI4. Ubiquitination occurs at Lys6, Lys75, Lys364, Lys407, Lys415, Lys422, Lys424 and Lys442. PSIP1 is phosphorylated upon DNA damage, probably by ATM or ATR. |
| Database Links | Entrez Gene: 11168 Human, Omim: 603620 Human, SwissProt: O75475 Human, Unigene: 726445 Human |
Reviews
You need to be logged in to write a review. Please login here
Sorry there are currently no reviews for this product