PSMC6 antibody (70R-12798)
Affinity purified Rabbit polyclonal PSMC6 antibody
Overview
Overview
| Synonyms | Polyclonal PSMC6 antibody, Anti-PSMC6 antibody, conserved ATPase domain protein 44 antibody, proteasome 26S subunit ATPase 6 antibody, CADP44 antibody, PSMC-6, proteasome subunit p42 antibody, PSMC 6 antibody, PSMC-6 antibody, P44 antibody, PSMC6, 26S protease regulatory subunit 10B antibody, PSMC 6, 26S proteasome AAA-ATPase subunit RPT4 antibody, PSMC6 antibody, p42 antibody, SUG2 antibody, MGC12520 antibody |
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| Cross Reactivity | Human, Mouse |
| Applications | ICC, IF, IHC-P, WB |
| Immunogen | PSMC6 antibody was raised in rabbit using a recombinant fragment corresponding to a region within amino acids 1 and 301 of PSMC6 |
Images
Specifications
| Host | Rabbit |
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| Isotype | IgG |
| Method of Purification | PSMC6 antibody was purified by antigen-affinity chromatography |
| Molecular Weight | 46 kDa |
| Form & Buffer | Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative. |
| Concentration | 1 mg/ml |
Usage & Assay Information
| Usage Recommendations | IF:1:100-1:500, ICC:1:100-1:500, IHC-P: 1:100-1:500, WB: 1:500-1:3000 |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. |
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