Rad54 antibody (70R-12568)
Affinity purified Rabbit polyclonal Rad54 antibody
Overview
Overview
| Synonyms | Polyclonal Rad54 antibody, Anti-Rad54 antibody, transcriptional regulator ATRX antibody, Rad 54 antibody, alpha thalassemia/mental retardation syndrome X-linked antibody, RAD54L antibody, Rad 54, ATR2 antibody, SHS antibody, RAD54 homolog antibody, X-linked helicase II antibody, X-linked nuclear protein antibody, ATP-dependent helicase ATRX antibody, Zinc finger helicase antibody, RAD54 antibody, alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog S. cerevisiae) antibody, helicase 2 X-linked antibody, ATRX antibody, ZNF-HX antibody, MGC2094 antibody, SFM1 antibody, DNA dependent ATPase and helicase antibody, MRXHF1 antibody, XH2 antibody, Rad-54 antibody, Rad-54, XNP antibody, Rad54 |
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| Cross Reactivity | Human, Mouse |
| Applications | ICC, IF, IHC-P, WB |
| Immunogen | Rad54 antibody was raised in rabbit using a recombinant fragment corresponding to a region within amino acids 2161 and 2443 of Rad54 |
Images
Specifications
| Host | Rabbit |
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| Isotype | IgG |
| Method of Purification | Rad54 antibody was purified by antigen-affinity chromatography |
| Molecular Weight | 283 kDa |
| Form & Buffer | Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative. |
| Concentration | 0.6 mg/ml |
Usage & Assay Information
| Usage Recommendations | IF:1:100-1:200, ICC:1:100-1:200, IHC-P: 1:100-1:500, WB: 1:500-1:3000 |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. |
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