RANK antibody (10R-6612)

Rat monoclonal RANK antibody

Synonyms Monoclonal RANK antibody, Anti-RANK antibody, RANK antibody, Receptor Activator of NF-kB antibody, Anti RANK antibody, Receptor Activator of NF-kB antibody, Tnfrsf11a antibody, Tnfrsf11a antibody, Rank antibody, Rank antibody
Specificity Mouse
Applications FC, Functional Assay, IHC, IP
Assay Information A test is defined as the amount (ug) of antibody that will stain a cell sample in a final volume of 100 ul. Cell number should be determined empirically but can range from 105 to 108 cells/test. It is recommended that the antibody be carefully titrated for optimal /formance in the assay of interest

Specifications

Host Rat
Clone R12-31
Isotype IgG2a kappa
Method of Purification RANK antibody was purified by affinity chromatography.
Form & Buffer Supplied in aqueous buffer with 0.09% sodium azide, may contain carrier protein/stabilizer.
Concentration 500 ug/ml

Usage & Assay Information

Usage Recommendations FC: = 0.25 ug/test

Storage & Safety

Storage Store at 2-8 deg C. Do not freeze. Protect from light.

General Information

Biological Significance The R12-31 monoclonal antibody reacts with mouse RANK, a recently cloned member of the TNFR superfamily with no significant homology to other members of this family. RANK ligand binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival. The cytoplasmic domain of RANK interacts with TRAF2, TRAF5 and TRAF6. Overexpression of RANK activates NF-kappaB and c-Jun-terminal kinase pathways. Recent studies have shown that RANK interaction with TRAF6 activates NF-kappaB, whereas JNK activation is mediated through binding of RANK to TRAF2.

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