RANK antibody (70R-13924)

Affinity purified Rat polyclonal RANK antibody

Synonyms Polyclonal RANK antibody, Anti-RANK antibody, Tnfrsf11a antibody, Receptor Activator of NF-kB antibody, Rank antibody
Applications IHC-P, WB
Immunogen RANK antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the N-terminal of human RANK as the immunogen

Images

Western Blot analysis using RANK antibody (70R-13924)

Western Blot using Human Recombinant RANK Protein

Specifications

Host Rabbit
Isotype IgG
Method of Purification RANK antibody was purified by affinity chromatography
Form & Buffer Supplied in lyophilized form

Usage & Assay Information

Usage Recommendations Optimal conditions to be determined by the end user

Storage & Safety

Storage Store at 4 deg C for short term storage. For long term storage aliquot and store at -20 deg C, avoid repeated freeze/thaw cycles.

General Information

Biological Significance The R12-31 monoclonal antibody reacts with mouse RANK, a recently cloned member of the TNFR superfamily with no significant homology to other members of this family. RANK ligand binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival. The cytoplasmic domain of RANK interacts with TRAF2, TRAF5 and TRAF6. Overexpression of RANK activates NF-kappaB and c-Jun-terminal kinase pathways. Recent studies have shown that RANK interaction with TRAF6 activates NF-kappaB, whereas JNK activation is mediated through binding of RANK to TRAF2.

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Images

  • <div><font face=Calibri size=2>Western Blot analysis using RANK antibody (70R-13924)</font></div>     | Western Blot using Human Recombinant RANK Protein

Availability: In stock

Price: €220.86
Size: 100 ug
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