RANK antibody (70R-13924)
Affinity purified Rat polyclonal RANK antibody
Overview
Overview
| Synonyms | Polyclonal RANK antibody, Anti-RANK antibody, Tnfrsf11a antibody, Receptor Activator of NF-kB antibody, Rank antibody |
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| Applications | IHC-P, WB |
| Immunogen | RANK antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the N-terminal of human RANK as the immunogen |
Images
Western Blot analysis using RANK antibody (70R-13924)
Western Blot using Human Recombinant RANK Protein
Specifications
| Host | Rabbit |
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| Isotype | IgG |
| Method of Purification | RANK antibody was purified by affinity chromatography |
| Form & Buffer | Supplied in lyophilized form |
Usage & Assay Information
| Usage Recommendations | Optimal conditions to be determined by the end user |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. For long term storage aliquot and store at -20 deg C, avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | The R12-31 monoclonal antibody reacts with mouse RANK, a recently cloned member of the TNFR superfamily with no significant homology to other members of this family. RANK ligand binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival. The cytoplasmic domain of RANK interacts with TRAF2, TRAF5 and TRAF6. Overexpression of RANK activates NF-kappaB and c-Jun-terminal kinase pathways. Recent studies have shown that RANK interaction with TRAF6 activates NF-kappaB, whereas JNK activation is mediated through binding of RANK to TRAF2. |
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