RANK protein (30R-AR024)

Purified recombinant Human RANK protein

Synonyms ODF protein, TRANCE protein, TNF-related activation-induced cytokine protein, Osteoclast differentiation factor protein, soluble Receptor Activator of NFkB Ligand protein, TNFSF11 protein, OPGL protein
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of RANK protein corresponding to amino acids MEKAMVDGSW LDLAKRSKLE AQPFAHLTIN ATDIPSGSHK VSLSSWYHDR GWAKISNMTF SNGKLIVNQD GFYYLYANIC FRHHETSGDL ATEYLQLMVY VTKTSIKIPS SHTLMKGGST KYWSGNSEFH FYSINVGGFF KLRSGEEISI EVSNPSLLDP DQDATYFGAF KVRDID.
Expression System E.coli
Grade & Purity > 98% pure
Molecular Weight 20.0 kDa
Form & Buffer Lyophilized from 5mM Na3PO4, pH 7.6 with 75mM NaCl. Reconstitute with water to 0.1-1.0 mg/ml.

Usage & Assay Information

Bioactivity Determined by its ability to induce NFkappaB in RAW264.7 cells in the absence of any cross-linking. The expected ED50 for this effect is 10.0-25.0 ng/ml.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate na

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Availability: In stock

Price: €211.69
Size: 10 ug
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