RANKL antibody (10R-R123A)
Mouse monoclonal RANKL antibody
Overview
Overview
| Synonyms | Monoclonal RANKL antibody, Anti-RANKL antibody, TRANCE antibody, ODF antibody, soluble Receptor Activator of NFkB Ligand antibody, Osteoclast differentiation factor antibody, TNFSF11 antibody, OPGL antibody, Anti RANKL antibody, ODF antibody, TRANCE antibody, Osteoclast differentiation factor antibody, TNFSF11 antibody, OPGL antibody, RANKL antibody, soluble Receptor Activator of NFkB Ligand antibody, TNF-related activation-induced cytokine antibody, TNF-related activation-induced cytokine antibody |
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| Specificity | Human RANKL |
| Cross Reactivity | To be determined by end-user |
| Applications | ELISA, Inhibition, WB |
| Immunogen | RANKL antibody was raised in mouse using highly pure recombinant human sRANK ligand as the immunogen. |
Specifications
| Host | Mouse |
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| Clone | M912290 |
| Isotype | IgG1 kappa |
| Molecular Weight | 19.4 kDa (predicted detection band MW) |
| Form & Buffer | Lyophilized from PBS. |
Usage & Assay Information
| Usage Recommendations | Optimal conditions to be determined by end user |
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Storage & Safety
| Storage | Store at -20 deg C until reconstitution. Following reconstitution product may be stored at 4 deg C in the short term. For long term storage aliquot and freeze at -20 deg C. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate naïve T-cell proliferation in a mixed lymphocyte reaction, to promote the survival of RANK + T cells, and to regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. |
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