RANKL antibody (70R-13199)

Affinity purified Rabbit polyclonal RANKL antibody

Synonyms Polyclonal RANKL antibody, Anti-RANKL antibody, TNFSF11 antibody, ODF antibody, hRANKL2 antibody, receptor activator of nuclear factor kappa-B ligand antibody, OPTB2 antibody, receptor activator of nuclear factor kappa B ligand antibody, sOdf antibody, TRANCE antibody, OPGL antibody, CD254 antibody, osteoprotegerin ligand antibody, tumor necrosis factor ligand superfamily member 11 antibody, RANKL antibody
Cross Reactivity Human
Applications IHC-P, WB

Images

Immunohistochemical staining using RANKL antibody (70R-13199)

Immunohistochemical staining of paraffin-embedded U87 xenograft using RANKL antibody at a dilution of 1:100

Specifications

Host Rabbit
Isotype IgG
Method of Purification RANKL antibody was purified by antigen-affinity chromatography
Molecular Weight 35 kDa
Form & Buffer Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative.
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations IHC-P: 1:100-1:500, WB: 1:500-1:3000

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance This gene encodes a member of the tumor necrosis factor cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy.

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Images

  • <div><font face=Calibri size=2>Immunohistochemical staining using RANKL antibody (70R-13199)</font></div>     | Immunohistochemical staining of paraffin-embedded U87 xenograft using RANKL antibody at a dilution of 1:100
  • <div><font face=Calibri size=2>Western blot analysis using RANKL antibody (70R-13199)</font></div>     | Western blot analysis of 30 ug of whole cell lysate (A: Hela) using a 10 % SDS PAGE gel and RANKL antibody at a dilution of 1:1000

Availability: In stock

Price: €323.11
Size: 100 ul
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