RANKL antibody (70R-13200)
Affinity purified Rabbit polyclonal RANKL antibody
Overview
Overview
| Synonyms | Polyclonal RANKL antibody, Anti-RANKL antibody, OPTB2 antibody, ODF antibody, CD254 antibody, receptor activator of nuclear factor kappa B ligand antibody, hRANKL2 antibody, OPGL antibody, RANKL antibody, sOdf antibody, receptor activator of nuclear factor kappa-B ligand antibody, TNFSF11 antibody, osteoprotegerin ligand antibody, TRANCE antibody |
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| Cross Reactivity | Human |
| Applications | WB |
Images
Western blot analysis using RANKL antibody (70R-13200)
Western blot analysis of 30 ug of whole cell lysate (A: Molt-4) using a 10 % SDS PAGE gel and RANKL antibody at a dilution of 1:1000
Specifications
| Host | Rabbit |
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| Isotype | IgG |
| Method of Purification | RANKL antibody was purified by antigen-affinity chromatography |
| Molecular Weight | 35 kDa |
| Form & Buffer | Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative. |
| Concentration | 0.3 mg/ml |
Usage & Assay Information
| Usage Recommendations | WB: 1:500-1:3000 |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | This gene encodes a member of the tumor necrosis factor cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. |
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