RANKL protein (30R-AR025)

Purified recombinant Human RANKL protein

Synonyms Osteoclast differentiation factor protein, soluble Receptor Activator of NFkB Ligand protein, TNFSF11 protein, TRANCE protein, OPGL protein, TNF-related activation-induced cytokine protein, ODF protein
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of RANKL protein corresponding to amino acids PAMMEGSWLD VAQRGKPEAQ PFAHLTINAA SIPSGSHKVT LSSWYHDRGW AKISNMTLSN GKLRVNQDGF YYLYANICFR HHETSGSVPT DYLQLMVYVV KTSIKIPSSH NLMKGGSTKN WSGNSEFHFY SINVGGFFKL RAGEEISIQV SNPSLLDPDQ DATYFGAFKV QDID
Expression System E.coli
Grade & Purity > 98% pure
Molecular Weight 19.4 kDa
Form & Buffer Lyophilized from 5mM tris, pH 7.6, with 75mM NaCl. Reconstitute in water to a concentration of 0.1-1.0 mg/ml.

Usage & Assay Information

Bioactivity Determined by its ability to induce NFkappaB in RAW264.7 cells in the absence of any cross-linking. The expected ED50 for this effect is 10.0-25.0 ng/ml.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate na

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Availability: In stock

Price: €211.69
Size: 10 ug
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