RANKL protein (30R-AR026)
Purified recombinant Human RANKL protein
Overview
Overview
| Synonyms | Receptor activator of nuclear factor kappa B ligand protein, Soluble Receptor Activator of NFkB Ligand protein, Osteoclast differentiation factor protein, Tumor necrosis factor ligand superfamily member 11 protein, TNFSF11 protein, Osteoprotegerin ligand protein, RANKL protein, sOdf protein, TRANCE protein, RANK Ligand protein, hRANKL2 protein, CD254 antigen protein, ODF protein, OPGL protein, sRANKL protein, TNF-related activation-induced cytokine protein |
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| Species | Human |
| Protein Type | Recombinant |
| Applications | User optimized |
Specifications
| Residues | sRANKL Human Recombinant protein containing 176 amino acids. |
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| Expression System | E.coli |
| Grade & Purity | > 98% pure |
| Method of Purification | RANKL protein was purified by a proprietary chromatographic technique. |
| Molecular Weight | 20,006 Da |
| Form & Buffer | Lyophilized from a concentrated (1mg/ml) solution containing 10mM Tris, pH 7.5. Reconstitute lyophilized product in sterile deionized water at concentration 100ug/ml. Please Note: Buffer may change with new Lots. |
Storage & Safety
| Storage | Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | RANKL binds to tnfrsf11b/opg and to tnfrsf11a/rank. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive t-cell proliferation. May be an important regulator of interactions between t-cells and dendritic cells and may play a role in the regulation of the t-cell-dependent immune response. sRANKL may also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy |
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