RANKL protein (Mouse) (30R-2217)

Purified recombinant Mouse RANKL protein

Synonyms Osteoclast Differentiation Factor protein, TRANCE protein, Osteoprotegerin ligand protein, ODF protein, RANKL protein, Receptor Activator of Nuclear Factor kappa B Ligand protein, OPGL protein
Species Mouse
Protein Type Recombinant
Applications ELISA, Functional Assay
Assay Information The ED50 of this protein, as measured by B9 cell proliferation assay, is less than or equal to 5 pg/ml. This corresponds to a specific activity of greater than or equal to 2 x 10e8 Units/mg.

Specifications

Expression System E.coli
Grade & Purity > 90% pure
Method of Purification RANKL protein was purified by affinity chromatography.
Molecular Weight 20 kDa
Form & Buffer Supplied as a sterile liquid with phosphate buffered saline, pH7.2, 1.0% BSA. 0.22 um filtered.

Usage & Assay Information

Bioactivity The ED50, as measured by induction ofosteoclast formation on mouse RAW264.7 cells, is 4.8ng/ml.

Storage & Safety

Storage Store at -70 deg C or less.
Endotoxin Levels Less than 0.01 ng/ug cytokine as determined by the LAL assay.

General Information

Biological Significance RANK Ligand, also known as TNF-related activation-induced cytokine, along with RANK are members of the TNF superfamily. RANK-L can be found as a soluble protein expressed by activated T lymphocytes, which plays a role in dendritic cell maturation. In addition it has also been shown to be cleaved by TACE releasing an ectodomain variant of the cell bound form. Lastly RANK-L is expressed as a Type II transmembrane protein expressed by osteoblast lineages. The receptor RANK, located on osteoclastic and dendritic cells can recognize all forms of RANK-L. RANK-L plays a critical role in bone development and mineralization. High levels of RANK-L have been associated with degenerative bone diseases.

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Price From: Price: €197.14
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