RARalpha protein (His tag) (80R-1038)
Purified recombinant Human RARalpha protein
|Synonyms||RAR protein, Retinoic acid receptor alpha protein, NR1B1 protein, alpha isoform 1, Retinoic acid receptor protein, RAR alpha protein, Retinoic acid receptor protein, alpha isoform 1 protein, RARalpha protein|
SDS-PAGE analysis of RARalpha protein (His tag) (80R-1038)
SDS-PAGE gel analysis of RARalpha protein (His tag) where the figure is annotated with amount of protein run on the gel.
|Residues||134-285 amino acids, 68-173 amino acids: MGSSHHHHHH SSGLVPRGSH MSEEIVPSPP SPPPLPRIYK PCFVCQDKSS GYHYGVSACE GCKGFFRRSI QKNMVYTCHR DKNCIINKVT RNRCQYCRLQ KCFEVGMSKE SVRNDRNKKK KEVPKPE|
|Grade & Purity||> 95% pure|
|Molecular Weight||14 kDa (127 aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher)|
|Form & Buffer||Supplied as a liquid in 20mM Tris, pH 7.5, containing 0.1M NaCl, and 5mM beta-mercaptoethanol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor (RXR), which form RXR/RAR heterodimers. In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1, SMRT (NCOR2), and histone deacetylase. When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases, and the basic transcription machinery.|
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