RARalpha protein (His tag) (80R-1038)
Purified recombinant Human RARalpha protein
Overview
Overview
| Synonyms | RAR protein, Retinoic acid receptor alpha protein, NR1B1 protein, alpha isoform 1, Retinoic acid receptor protein, RAR alpha protein, Retinoic acid receptor protein, alpha isoform 1 protein, RARalpha protein |
|---|---|
| Species | Human |
| Protein Type | Recombinant |
| Applications | SDS-PAGE |
Images
SDS-PAGE analysis of RARalpha protein (His tag) (80R-1038)
SDS-PAGE gel analysis of RARalpha protein (His tag) where the figure is annotated with amount of protein run on the gel.
Specifications
| Residues | 134-285 amino acids, 68-173 amino acids: MGSSHHHHHH SSGLVPRGSH MSEEIVPSPP SPPPLPRIYK PCFVCQDKSS GYHYGVSACE GCKGFFRRSI QKNMVYTCHR DKNCIINKVT RNRCQYCRLQ KCFEVGMSKE SVRNDRNKKK KEVPKPE |
|---|---|
| Expression System | E.coli |
| Grade & Purity | > 95% pure |
| Molecular Weight | 14 kDa (127 aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher) |
| Tag/Conjugate | His tag |
| Form & Buffer | Supplied as a liquid in 20mM Tris, pH 7.5, containing 0.1M NaCl, and 5mM beta-mercaptoethanol. |
| Concentration | 1 mg/ml |
Storage & Safety
| Storage | Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor (RXR), which form RXR/RAR heterodimers. In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1, SMRT (NCOR2), and histone deacetylase. When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases, and the basic transcription machinery. |
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