Rat GDNF ELISA Kit (55R-1582)
ELISA kit for detection of GDNF in the research laboratory
Overview
Overview
| Synonyms | Glial-Derived Neurotrophic Factor ELISA Kit, ATF-1 ELISA Kit |
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| Applications | ELISA |
| Assay Information | Sensitivity: 31.2 pg/ml-2000 pg/ml |
Images
ELISA assay using Rat GDNF ELISA Kit (55R-1582)
Graph showing ELISA absorbance curve (O.D.) of Rat GDNF (pg/ml)
Specifications
| Form & Buffer | This Kit contains: Lyophilized recombinant rat GDNF standard: 10ng/tube |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage (4 months) or -20 deg C for long term storage (8 months) |
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General Information
| Biological Significance | GDNF is a disulfide-linked homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFR a(a1-a4) receptors. GDNF specifically promotes dopamine uptake and survival and morphological differentiation of midbrain neurons. Using Parkinson?s disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. |
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