RBP protein (95% pure) (30R-AR022L)
Highly purified native Human RBP protein
Overview
Overview
| Synonyms | Native RBP protein, Purified RBP, Retinol Binding Protein, Human RBP, Human Retinol Binding Protein, 30R-AR022 RBP protein |
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| Species | Human |
| Protein Type | Native |
| Applications | Control, ELISA, Lateral Flow |
Specifications
| Source | Human urine |
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| Grade & Purity | > 95% pure |
| Molecular Weight | 21 kDa |
| Form & Buffer | Supplied as lyophilized powder. |
Storage & Safety
| Storage | Store at 4 deg C. |
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General Information
| Product Use | This high purity human RBP protein can be used as a control in research labs or in the development of clinical or diagnostic immunoassays for detection of RBP. |
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| Biological Significance | Retinol-binding proteins are a family of proteins with diverse functions. They are carrier proteins that bind retinol. Assessment of retinol-binding protein is used to determine visceral protein mass in nutritional studies related to health. RBP plays an important role in pregnancy. Retinol is crucial in the growth and differentiation of various body tissues, and it has been shown that embryos are extremely sensitive to alterations in retinol concentration that can lead to spontaneous abortion and malformations occurring during development. |
| Expression | Traditionally, RBP is synthesized within the liver with secretion being dependent upon retinol concentrations. There are three main types of RBP: 1.Plasma RBP - the retinol transport vehicle in serum; 2. 2.CRBP I/II - cellular binding proteins involved in transport of retinol and metabolites into retinyl esters for storage or into retinoic acid; 3. CRABPs - cellular retinoic acid binding proteins that are capable of binding retinol and retinoic acid with high affinity. |
| Implications in Disease | RBP is readily filtered by the glomerulus and absorbed by the proximal renal tubules, as such it is valuable for the assessment of renal tubular function. |
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