Renin 1 protein (80R-4371)

Purified Recombinant Renin 1 protein (His tagged)

Synonyms Ren1 protein, Ren protein, Ren-A protein, Ren1c protein, Ren1d protein, Rn-1 protein, Rnr protein, Angiotensinogenase protein, Kidney renin protein
Species Mouse
Protein Type Recombinant
Applications SDS-PAGE

Images

SDS-PAGE analysis using Renin 1 protein (His tag) (80R-4371)

Specifications

Residues 22-402 aa: LPTRTATFER IPLKKMPSVR EILEERGVDM TRLSAEWGVF TKRPSLTNLT SPVVLTNYLN TQYYGEIGIG TPPQTFKVIF DTGSANLWVP STKCSRLYLA CGIHSLYESS DSSSYMENGS DFTIHYGSGR VKGFLSQDSV TVGGITVTQT FGEVTELPLI PFMLAKFDGV LGMGFPAQAV GGVTPVFDHI LSQGVLKEEV FSVYYNRGSH LLGGEVVLGG SDPQHYQGNF HYVSISKTDS WQITMKGVSV GSSTLLCEEG CAVVVDTGSS FISAPTSSLK LIMQALGAKE KRIEEYVVNC SQVPTLPDIS FDLGGRAYTL SSTDYVLQYP NRRDKLCTLA LHAMDIPPPT GPVWVLGATF IRKFYTEFDR HNNRIGFALA RHHHHHH
Expression System Insect cells
Grade & Purity > 95% pure
Molecular Weight 42.5 kDa
Tag/Conjugate His tag
Form & Buffer Supplied in liquid form in Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.
Concentration 250 ug/ml

Storage & Safety

Storage Store at 4 deg C short term (1-2 weeks). For long term storage, aliquot and store at -20 or -70 deg C. Avoid repeated freezing and thawing cycles.
Endotoxin Levels < 1.0 EU per 1 microgram of protein (determined by LAL method)

General Information

Biological Significance REN1, also known as Renin-1, is a member of the peptidase A1 family. It is synthesized by the juxtaglomerular cells of the kidney in response to decreased blood pressure and sodium concentration. Androgen and thyroid hormones influence levels of Renin-1 in mouse submandibular gland (SMG) primarily by regulating the amount of Renin-1 mRNA available for translation. This protein is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Also, REN1 was found to be co localized with the lysosomal marker, beta-glucuronidase, by double-fluorescent labeling.

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Images

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SDS-PAGE analysis using Renin 1 protein (His tag) (80R-4371)



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Availability: In stock

Price: €300.20
Size: 50 ug
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