Renin protein (30-1209S)
Purified recombinant Human Renin protein
Overview
Overview
| Synonyms | Angiotensinogenase protein, REN protein, Recombinant Human Renin protein |
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| Species | Human |
| Protein Type | Recombinant |
Specifications
| Residues | Contains a C-terminal his tag |
|---|---|
| Expression System | HEK293 cells |
| Grade & Purity | > 95% pure |
| Method of Purification | Purified by affinity chromatography |
| Molecular Weight | 40 kDa |
| Tag/Conjugate | His tag |
| Form & Buffer | Supplied as a Lyophilized from 0.22 µm filtered 50 mM Tris-HCl and 50 mM NaCl, pH 8.0 with 5% trehalose. |
| Concentration | > 100 ug/ml |
Storage & Safety
| Storage | Aliquot and store at -70 deg C. Avoid repeated freeze thaw cycles. |
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General Information
| Biological Significance | Renin is an aspartyl protease that is specific for only one substrate, angiotensinogen that mediates extracellular volume (i.e., that of the blood plasma, lymph and interstitial fluid), and arterial vasoconstriction.Prorenin is the precursor of renin andhas low level of enzymatic activity comparedto renin. This recombinant renin is produced from prorenin by proteolytic cleavage of a 43 amino acid N-terminal pro-segment using limited enzymatic digestion by immobilized trypsin and purified by affinity chromatography, resulting in >99% conversion toactive renin. |
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