Ret antibody (70R-RG002)

Affinity purified Goat polyclonal Ret antibody

Synonyms Polyclonal Ret antibody, Anti-Ret antibody
Specificity Murine
Cross Reactivity To be determined by end-user
Applications ELISA, IHC-F, IHC-P, WB
Immunogen Ret antibody was raised in goat using NSO derived murine ret extracellular domain as the immunogen.

Specifications

Host Goat
Form & Buffer Lyophilized from PBS, pH 7.2 containing 5% trehalose. Reconstitute with 1 ml of PBS.

Usage & Assay Information

Usage Recommendations ELISA: 0.5-1 ug/ml, IHC-F: 5 ug/ml, IHC-P: 10-15 ug/ml, WB: 0.1-0.2 ug/ml

Storage & Safety

Storage Aliquot and store at -70 deg C or lower. Avoid repeated freeze/thaw cycles

General Information

Biological Significance The Ret proto-oncogene (c-Ret) is a receptor tyrosine kinase that functions as a multicompetent receptor complex in conjunction with other membrane-bound ligand-binding GDNF family receptors. Ligands that bind the Ret receptor include the glial cell line-derived neurotropic factor (GDNF) and its congeners neurturin, persephin and artemin. Alterations in the corresponding Ret gene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma and a congenital developmental disorder known as Hirschsprung’s disease. The Tyr905 residue located in the Ret kinase domain plays a crucial role in Ret catalytic and biological activity. Substitution of Phe for Tyr905 dramatically inhibits Ret autophosphorylation activity.

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