RheB protein (T7 tag) (80R-1076)
Purified recombinant Human RheB protein (T7 tag)
Overview
Overview
| Synonyms | Ras homolog enriched in brain 2 protein, MGC111559 protein, Ras homolog enriched in brain protein, GTP-binding protein Rheb protein, Ras homolog enriched in brain GTP binding protein Rheb protein, RheB protein, RHEB 2., RHEB2 protein |
|---|---|
| Species | Human |
| Protein Type | Recombinant |
| Applications | SDS-PAGE |
Images
Coomassie Blue stained SDS-PAGE of RheB protein (T7 tag) (80R-1076)
Figure annotation denotes ug of protein loaded and % gel used.
Specifications
| Residues | 1-181 amino acids: MASMTGGQQM GRGSASMPQS KSRKIAILGY RSVGKSSLTI QFVEGQFVDS YDPTIENTFT KLITVNGQEY HLQLVDTAGQ DEYSIFPQTY SIDINGYILV YSVTSIKSFE VIKVIHGKLL DMVGKVQIPI MLVGNKKDLH MERVISYEEG KALAESWNAA FLESSAKENQ TAVDVFRRII LEAEKMDGAA SQGKSSC |
|---|---|
| Expression System | E.coli |
| Grade & Purity | > 95% pure |
| Molecular Weight | 21.7 kDa (197 aa), confirmed by MALDI-TOF. |
| Tag/Conjugate | T7 tag |
| Form & Buffer | Supplied as a liquid in 20mM Tris, pH 8.0, containing 1mM DTT, and 10% glycerol. |
| Concentration | 1 mg/ml |
Storage & Safety
| Storage | Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | Ras homolog enriched in brain (RheB) is a member of the Ras superfamily that was originally identified as an immediate-early gene in brain but is also widely expressed in other tissues. RheB encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. RheB is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. Recombinant human RheB protein, fused to T7-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. |
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