RIP antibody (70R-11737)

Rabbit polyclonal RIP antibody

Synonyms Polyclonal RIP antibody, anti-RIP antibody, RIPK1 antibody, Rinp antibody, Receptor interacting protein antibody, FLJ39204 antibody, RIPK1 antibody
Cross Reactivity Human, Mouse, Rat
Applications IHC, IP, WB
Immunogen RIP antibody was raised in Rabbit using synthetic peptide surrounding amino acid 645 of human RIP as the immunogen.
Assay Information RIP Blocking Peptide, catalog no. 33R-10699, is also available for use as a blocking control in assays to test for specificity of this RIP antibody

Specifications

Host Rabbit
Isotype IgG
Method of Purification RIP antibody was purified by affinity chromatography
Form & Buffer Supplied in PBS buffer, pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal
Concentration 500 ug/ml

Usage & Assay Information

Usage Recommendations WB: 2-6 ug/ml

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance RIP is a 74 kDa Ser/Thr kinase which interacts with CD95 receptor and the tumor necrosis factor receptor. It is a cell death domain adapter protein which can bind to the adapter proteins TRADD, RAID, and TRAF2. RIP contains an N-terminal region with homology to protein kinase, an intermediate domain capable of association with MAPKKK and a C-terminal region containing an intracellular death domain motif. RIP activates both p38 MAP kinase and SAPK families. In vitro, RIP induces apoptosis, as well as SAPK/JNK and NF-kB activation. RIP possesses kinase activity as it autophosphorylates itself on serine and threonine residues.

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Availability: In stock

Price: €285.48
Size: 100 ug
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