RND1 protein (His tag) (80R-1902)
Purified recombinant RND1 protein
|Synonyms||FLJ42294 protein, RND 1, RHO protein, RND-1, ARHS protein, RND1, RND 1 protein, RND-1 protein, RHO6 protein|
Coomassie Blue stained SDS-PAGE of RND1 protein (His tag) (80R-1902)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-200 amino acids: MGSSHHHHHH SSGLVPRGSH MKERRAPQPV VARCKLVLVG DVQCGKTAML QVLAKDCYPE TYVPTVFENY TACLETEEQR VELSLWDTSG SPYYDNVRPL CYSDSDAVLL CFDISRPETV DSALKKWRTE ILDYCPSTRV LLIGCKTDLR TDLSTLMELS HQKQAPISYE QGCAIAKQLG AEIYLEGSAF TSEKSIHSIF RTASMLCLNK PSPLPQKSPV|
|Grade & Purity||> 95% pure|
|Molecular Weight||24.5 kDa (220aa), confirmed by MALDI-TOF (Molecular size on SDS-PAGE will appear higher)|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 30% glycerol, 0.1M NaCl and 1mM DTT.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||RND1, also known as Rho 6, iRho-related GTPases form a distinct branch of the Rho family, since they differ from other Rho proteins in size, charge, and biochemical properties. It appears to be constitutively in the activated GTP-bound form and acts as negative regulators of actin assembly and of cell adhesion. It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors. Recombinant human RND1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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