RRAS2 protein (His tag) (80R-1201)
Purified recombinant Human RRAS2 protein
|Synonyms||TC 21 protein, RRAS 2 protein, RRAS-2, RRAS2, Oncogene RRAS2 protein, RRAS-2 protein, Ras like protein TC21 protein, Related RAS viral oncogene homolog 2 protein, Related RAS viral (r ras) oncogene homolog 2 protein, Teratocarcinoma oncogene TC21., RRAS 2 protein, Ras related protein R Ras2 protein, RAS viral (r-ras) oncogene homolog 2 isoform a C86394 protein, RRAS 2, Oncogene TC21 protein, Teratocarcinoma oncogene protein, TC21 protein|
Coomassie Blue stained SDS-PAGE of RRAS2 protein (His tag) (80R-1201)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-201 amino acids: MGSSHHHHHH SSGLVPRGSH MAAAGWRDGS GQEKYRLVVV GGGGVGKSAL TIQFIQSYFV TDYDPTIEDS YTKQCVIDDR AARLDILDTA GQEEFGAMRE QYMRTGEGFL LVFSVTDRGS FEEIYKFQRQ ILRVKDRDEF PMILIGNKAD LDHQRQVTQE EGQQLARQLK VTYMEASAKI RMNVDQAFHE LVRVIRKFQE QECPPSPEPT RKEKDKKGCH C|
|Grade & Purity||> 95% pure|
|Molecular Weight||25.2 kDa (221aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 1mM DTT, 10% glycerol, and 2mM EDTA.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||RAS viral (r-ras) oncogene homolog 2 isoform a, also known as RRAS2, belongs to the Ras like GTPase family that cycle between GTP-bound active and GDP-bound inactive states at the cytoplasmic face of the plasma membrane. It is implicated in the pathogenesis of human cancers. Thus, overexpression of active RRAS2 in EpH4 cells induces tumorigenicity through the phosphoinositide 3-kinase, p38 MAPK, and mTOR pathways, and these cells lose their sensitivity to the normal growth inhibitory role of TGF-beta. Recombinant human RRAS2, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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