RUNX3 protein (His tag) (80R-1340)
Purified recombinant Human RUNX3 protein
|Synonyms||core-binding factor protein, RUNX-3, Core binding factor runt domain alpha subunit 3 protein, PEBP2 alpha C protein, Core binding factor subunit alpha 3.M574 protein, core binding factor protein, Runt-related transcription factor 3 Acute myeloid leukemia 2 protein protein, RUNX 3, PEA2 alpha C protein, FLJ34510 protein, Pebp2a3 protein, Core binding factor alpha 3 subunit protein, Transcription factor AML2., PEBP2aC protein, CBFA 3 protein, SL3/AKV core binding factor alpha C subunit protein, RUNX 3 protein, Acute myeloid leukemia gene 2 protein, SL3 3 enhancer factor 1 alpha C subunit protein, Polyomavirus enhancer binding protein 2 alpha C subunit protein, RUNX-3 protein, runt related transcription factor 3 protein, Oncogene AML 2 protein, AML 2 protein, runt domain alpha subunit 3 protein, CBF alpha 3 protein, RUNX3, AML2 protein, RUNX 3 protein, CBFA3 protein, MGC16070 protein|
Coomassie Blue stained SDS-PAGE of RUNX3 protein (His tag) (80R-1340)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||53-186 amino acids: MGSSHHHHHH SSGLVPRGSH MRSMVDVLAD HAGELVRTDS PNFLCSVLPS HWRCNKTLPV AFKVVALGDV PDGTVVTVMA GNDENYSAEL RNASAVMKNQ VARFNDLRFV GRSGRGKSFT LTITVFTNPT QVATYHRAIK VTVDGPREPR RHRQK|
|Grade & Purity||> 95% pure|
|Molecular Weight||17.1 kDa (155aa) confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol, 0.1M NaCl and 1mM DTT.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||RUNX3, also known as runt-related transcription factor 3, belongs to the RUNX family that regulate the expression of genes involved in cellular differentiation and cell cycle progression. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It is a strong candidate as a gastric cancer tumor suppressor. Recombinant human RUNX3, fused to His-tag at N-terminus, protein was expressed in E. coli and purified by using conventional chromatography techniques|
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