S100Z protein (His tag) (80R-1351)
Purified recombinant Human S100Z protein
|Synonyms||S100-zeta protein, SZ 100 protein, S100Z, S100 calcium binding protein Z protein, SZ-100, Protein S100-Z Gm625 protein, S100 calcium binding protein zeta., SZ 100, Protein S100 Z protein, SZ-100 protein|
Coomassie Blue stained SDS-PAGE of S100Z protein (His tag) (80R-1351)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-99 amino acids: MGSSHHHHHH SSGLVPRGSH MPTQLEMAMD TMIRIFHRYS GKERKRFKLS KGELKLLLQR ELTEFLSCQK ETQLVDKIVQ DLDANKDNEV DFNEFVVMVA ALTVACNDYF VEQLKKKGK|
|Grade & Purity||> 95% pure|
|Molecular Weight||13.7 kDa (119aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 1mM DTT, 20% glycerol, 1mM EDTA and 50mM NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||S100 calcium binding protein Z, also known as S100Z, is member of the S100 protein family. S100 proteins are small dimeric members of the EF-hand superfamily of Ca(2+) binding proteins thought to participate in mediating intracellular Ca(2+) signals by binding to and thereby regulating target proteins in a Ca(2+)-dependent manner. There are differences in the expression level of S100Z mRNA in various tissues. The highest levels were found in spleen and leukocytes.S100Z gene expression appears to be deregulated in some tumor tissues, compared to expression in their normal counterparts. Recombinant human S100Z, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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