SAA1 protein (30R-2980)
Purified recombinant Monkey SAA1 protein
Overview
Overview
| Synonyms | Serum amyloid A protein, SAA protein, Amyloid protein A protein, Amyloid fibril protein AA protein, SAA1 protein, SAA2 protein, PIG4 protein, TP53I4 protein, MGC111216 protein, SAA1, SAA-1, SAA 1, SAA-1 protein, SAA 1 protein, Serum amyloid A, SAA, Amyloid protein A, Amyloid fibril protein AA, SAA1, SAA2, PIG4, TP53I4, MGC111216, SAA-1, SAA 1 |
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| Species | Monkey |
| Protein Type | Recombinant |
Specifications
| Residues | RSWFSFLGEA YDGARDMWRA YSDMKEANYK NSDKYFHARG NYDAAQRGPG GVWAAEVISD ARENIQKLLG RGAEDTLADQ AANEWGRSGK DPNHFRPAGL PEKY |
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| Expression System | E.coli |
| Method of Purification | SAA1 protein was purified using a a proprietary chromatographic technique. |
| Molecular Weight | 11.8 kDa |
| Form & Buffer | Supplied in lyophilized form with 1x PBS pH-7.4. Please Note: Buffer may change with new Lots. |
Usage & Assay Information
| Bioactivity | Determined by its ability to chemoattract human monocytes using a concentration range of 1.0-10.0 ng/ml |
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Storage & Safety
| Storage | Store in lyophilized form at -18 deg C. Following reconstitution store in liquid form at 4 deg C for short term storage or -18 deg c for long term storage |
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General Information
| Biological Significance | SAA1 protein, an acute phase apolipoprotein reactant which is produced by hepatocytes andregulated byinflammatory cytokines. SAA1 protein is produced in the liver and circulates in the blood at low concentrations. SAA1 protein levels increase in the blood and tissues during inflammation. SAA1 may facilitate the repair of injured tissues; it also acts as an antibacterial agent, and signals the migration of germ-fighting cells to sites of infection. SAA1 also functions as an apolipoprotein of the HDL complex. Elevated levels of SAA1 ultimately affect secondary amyloidosis, extracellular amassing of amyloid fibrils, resulting from a circulating precursor, in a variety of tissues and organs. The most widespread type of amyloidosis appears secondary to chronic inflammatory disease, mainly rheumatoid arthritis. |
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