SAPK antibody (20R-1656)

Rabbit polyclonal SAPK antibody

Synonyms Polyclonal SAPK antibody, Anti-SAPK antibody, Phospho-JNK/SAPK antibody
Specificity The antibody detects the p46 and p54 JNK/SAPK dually phosphorylated at Thr183 and Tyr185.
Cross Reactivity Human, Mouse, Rat
Applications ICC, IHC, IP, WB

Specifications

Host Rabbit
Method of Purification SAPK antibody was purified by affinity purification.
Form & Buffer Supplied in PBS buffer, pH 7.2, containing 50% glycerol, 1% BSA, 0.02% sodium azide.
Concentration 500 ug/ml

Usage & Assay Information

Usage Recommendations IP: 10-20 ug/ml, ICC: 10-20 ug/ml, IHC: 20-30 ug/ml, WB: 1-2 ug/ml

Storage & Safety

Storage Store at -20 deg C. For long-term storage, aliquot and freeze at -70 deg C. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance The JNK pathway is activated by largely distinct stimuli including inflammatory cytokines (such as TNF and IL 1), UV light, inhibitors of protein synthesis and osmotic stress. Activated MEKK1 phosphorylates SEK1 (also known as MKK4), which in turn activates SAPK (also known as JNK). JNK binds tightly to the N terminal region of c Jun and ATF 2, and phosphorylates c Jun at Ser63 and Ser73 and ATF 2 at Thr69 and Thr71.

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Availability: In stock

Price: €511.25
Size: 100 ug
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