SART1 antibody (70R-12724)
Affinity purified Rabbit polyclonal SART1 antibody
Overview
Overview
| Synonyms | Polyclonal SART1 antibody, Anti-SART1 antibody, squamous cell carcinoma antigen recognised by T cells antibody, SART-1 antibody, MGC2038 antibody, Ara1 antibody, SART 1 antibody, SART1, SART 1, HOMS1 antibody, SART-1, SART1259 antibody, SART1 antibody, hSnu66 antibody, SNRNP110 antibody, Snu66 antibody, U4/U6.U5 tri-snRNP-associated protein 1 antibody |
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| Cross Reactivity | Human, Mouse |
| Applications | ICC, IF, IHC-P, WB |
| Immunogen | SART1 antibody was raised in rabbit using a recombinant fragment corresponding to a region within amino acids 137 and 447 of SART1 |
Images
Specifications
| Host | Rabbit |
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| Isotype | IgG |
| Method of Purification | SART1 antibody was purified by antigen-affinity chromatography |
| Molecular Weight | 90 kDa |
| Form & Buffer | Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative. |
| Concentration | 0.76 mg/ml |
Usage & Assay Information
| Usage Recommendations | IF:1:100-1:1000, ICC:1:100-1:1000, IHC-P: 1:100-1:1000, WB: 1:500-1:5000 |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. |
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