SDF1 protein (Mouse) (His tag) (80R-3353)
Purified recombinant SDF1 protein (Mouse) (His tag)
Overview
Overview
| Synonyms | 12 O tetradecanoylphorbol 13 acetate repressed 1 protein, TPAR1 protein, C X C motif chemokine 12 protein, Pre B cell growth stimulating factor protein, PBSF protein, Thymic lymphoma cell stimulating factor protein, TLSF protein, Stromal cell derived factor 1 protein, SDF 1 protein, SDF-1 protein |
|---|---|
| Species | Mouse |
| Protein Type | Recombinant |
| Applications | ELISA, SDS-PAGE, WB |
Specifications
| Expression System | E.coli |
|---|---|
| Grade & Purity | > 90% pure |
| Molecular Weight | 7.9 kDa |
| Tag/Conjugate | His tag |
| Form & Buffer | Supplied in Tris-based buffer with 50% glycerol |
Storage & Safety
| Storage | Store at 4 deg C in a working aliquot for 1 week. For long term storage, aliquot and freeze at -20 to -80 deg C, avoid repeat freeze/thaw cycles |
|---|
General Information
| Biological Significance | SDF1 is a chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the Lyn kinase. Stimulates migration of monocytes through its receptor, CXCR4, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through Lyn kinase. Stimulates the proliferation of bone marrow-derived b progenitor cells in the presence of IL-7 as well as growth of the stromal cell-dependent B-cell clone DW34 cells. |
|---|
Reviews
You need to be logged in to write a review. Please login here
Sorry there are currently no reviews for this product