SDF1 protein (Mouse) (His tag) (80R-3353)

Purified recombinant SDF1 protein (Mouse) (His tag)

Synonyms 12 O tetradecanoylphorbol 13 acetate repressed 1 protein, TPAR1 protein, C X C motif chemokine 12 protein, Pre B cell growth stimulating factor protein, PBSF protein, Thymic lymphoma cell stimulating factor protein, TLSF protein, Stromal cell derived factor 1 protein, SDF 1 protein, SDF-1 protein
Species Mouse
Protein Type Recombinant
Applications ELISA, SDS-PAGE, WB

Specifications

Expression System E.coli
Grade & Purity > 90% pure
Molecular Weight 7.9 kDa
Tag/Conjugate His tag
Form & Buffer Supplied in Tris-based buffer with 50% glycerol

Storage & Safety

Storage Store at 4 deg C in a working aliquot for 1 week. For long term storage, aliquot and freeze at -20 to -80 deg C, avoid repeat freeze/thaw cycles

General Information

Biological Significance SDF1 is a chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the Lyn kinase. Stimulates migration of monocytes through its receptor, CXCR4, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through Lyn kinase. Stimulates the proliferation of bone marrow-derived b progenitor cells in the presence of IL-7 as well as growth of the stromal cell-dependent B-cell clone DW34 cells.

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Availability: In stock

Price: €182.41
Size: 50 ug
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