sDLL1 protein (30R-AD009)
Purified recombinant Human sDLL1 protein
Overview
Overview
| Synonyms | sDLL-1 protein, Delta-like protein 1 protein, Delta-1 protein, sDLL1, sDLL 1 protein, sDLL 1, sDLL-1 protein, sDLL-1 |
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| Species | Human |
| Protein Type | Recombinant |
| Applications | User optimized |
Specifications
| Residues | Region of SDLL1 protein corresponding to amino acids SGVFELKLQE FVNKKGLLGN RNCCRGGAGP PPCACRTFFR VCLKHYQASV SPEPPCTYGS AVTPVLGVDS FSLPDGGGAD SAFSNPIRFP FGFTWPGTFS LIIEALHTDS PDDLATENPE RLISRLATQR HLTVGEEWSQ DLHSSGRTDL KYSYRFVCDE HYYGEGCSVF CRPRDDAFGH FTCGERGEKV CNPGWKGPYC TEPICLPGCD EQHGFCDKPG ECKCRVGWQG RYCDECIRYP GCLHGTCQQP WQCNCQEGWG GLFCNQDLNY CTHHKPCKNG ATCTNTGQGS YTCSCRPGYT GATCELGIDE CDPSPCKNGG SCTDLENSYS CTCPPGFYGK ICELSAMTCA DGPCFNGGRC SDSPDGGYSC RCPVGYSGFN CEKKIDYCSS SPCSNGAKCV DLGDAYLCRC QAGFSGRHCD DNVDDCASSP CANGGTCRDG VNDFSCTCPP GYTGRNCSAP VSRCEHAPCH NGATCHERGH RYVCECARGY GGPNCQFLLP ELPPGPAVVD LTEKLEGQGG PF. |
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| Expression System | 293 cells |
| Grade & Purity | > 95% pure |
| Molecular Weight | 57-60 kDa |
| Form & Buffer | Lyophilized from PBS, pH 7.5, |
Usage & Assay Information
| Bioactivity | Determined by the dose dependent growth suppression of the human acute mon DEG Cytic leukemia cell line, THP-1. sDLL-1 inhibits the proliferation in THP-1 cells using a concentration of 3.0-5.0 ug/ml. |
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Storage & Safety
| Storage | Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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| Endotoxin Levels | Endotoxin level is less than 0.1 ng per ug (1 EU/ug). |
General Information
| Biological Significance | Human sDLL-1 comprises the extracellular signaling domain of DLL1, a member of a structurally-related family of single-pass type I trans-membrane proteins that serve as ligands for Notch receptors. It is expressed in the heart and pancreas, and to a lesser extent in various other tissues. DLL-1 functions to specifically activate the Notch-1 and Notch-2 receptors. |
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