Sheep anti Human IgA (20C-CR6043SP)
Sheep anti Human IgA antibody
Overview
Overview
| Synonyms | Polyclonal Human IgA antibody, Anti-Human IgA antibody, Immunoglobulin A antibody |
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| Specificity | Human |
| Cross Reactivity | To be determined by end-user |
| Applications | Immunodiffusion, ODD, WB |
| Immunogen | Human IgA antibody was raised in sheep using human secretory piece purified from human colostrum as the immunogen. |
Specifications
| Host | Sheep |
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| Form & Buffer | Supplied as a liquid in GBS. |
| Concentration | Batch dependent - please inquire should you have specific requirements |
Usage & Assay Information
| Usage Recommendations | ODD: 10 uL antiserum vs 10 uL Milk, WB: 100 uL antiserum vs 10 uL Milk, Immunodiffusion: 16 uL antiserum/cm^2 in gel vs 5 uL Milk, dilutions: Neat - 1:15. |
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Storage & Safety
| Storage | Store at 4 deg C. |
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General Information
| Biological Significance | The secretory piece is a component of immunoglobulin A which consists of a portion of the polymeric immunoglobulin receptor. Polymeric IgA binds to the polymeric immunoglobulin receptor on the basolateral surface of epithelial cells and is taken up into the cell via transcytosis. The receptor-IgA complex passes through the cellular compartments before being secreted on the luminal surface of the epithelial cells, still attached to the receptor. Proteolysis of the receptor occurs and the dimeric IgA molecule, along with the secretory component, is free to diffuse throughout the lumen. |
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