SHH antibody (70R-13756)
Affinity purified Rabbit polyclonal SHH antibody
Overview
Overview
| Synonyms | Polyclonal SHH antibody, Anti-SHH antibody, SMMCI antibody, TPTPS antibody, Sonic Hedgehog antibody, TPT antibody, Sonic Hedgehog Homolog antibody, HLP3 antibody, HHG1 antibody, HPE3 antibody |
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| Applications | IHC-P, WB |
| Immunogen | SHH antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the N-terminal of human SHH, identical to the related Rabbit and rat sequences, as the immunogen |
Images
Immunohistochemical staining using SHH antibody (70R-13756)
Immunohistochemistry of paraffin-embedded section of Rat Brain Tissue
Specifications
| Host | Rabbit |
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| Isotype | IgG |
| Method of Purification | SHH antibody was purified by affinity chromatography |
| Form & Buffer | Supplied in lyophilized form |
Usage & Assay Information
| Usage Recommendations | Optimal conditions to be determined by the end user |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. For long term storage aliquot and store at -20 deg C, avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | SHH is a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE). It is also thought that mutations in its gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. |
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