SMAD antibody (70R-13873)
Affinity purified Rabbit polyclonal SMAD antibody
Overview
Overview
| Synonyms | Polyclonal SMAD antibody, Anti-SMAD antibody |
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| Applications | WB |
| Immunogen | SMAD antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the C-terminal of human Smad ,5, identical to the related Rabbit and rat sequences, as the immunogen |
Images
Western blot analysis using SMAD antibody (70R-13873)
Lane 1: Rat Heart Tissue Lysate, Lane 2: Rat Skeletal muscle Tissue Lysate, Lane 3: Rat Kidney Tissue Lysate, Lane 4: Rat Brain Tissue Lysate, Lane 5: MM453 Cell Lysate, Lane 6: MM231 Cell Lysate, Lane 7: HELA Cell Lysate, Lane 8: SMMC Cell Lysate, Lane 9: SW620 Cell
Specifications
| Host | Rabbit |
|---|---|
| Isotype | IgG |
| Method of Purification | SMAD antibody was purified by affinity chromatography |
| Form & Buffer | Supplied in lyophilized form |
Usage & Assay Information
| Usage Recommendations | Optimal conditions to be determined by the end user |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. For long term storage aliquot and store at -20 deg C, avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | SMADs are proteins that modulate the activity of transforming growth factor beta ligands. The SMADs, often in complex with other SMADs/CoSMAD, act as transcription factors that regulate the expression of certain genes. Zhu, H et al concluded that targeted ubiquitination of SMADs may serve to control both embryonic development and a wide variety of cellular responses to TGF-beta signals. R-Smads or receptor regulated Smads are a class of proteins that include SMAD1, SMAD2, SMAD3, SMAD5, and SMAD8. In response to signals by the TGF- |
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