SMAD4 protein (His tag) (80R-1096)
Purified recombinant Human SMAD4 protein
|Synonyms||SMAD mothers against DPP homolog 4., Mothers against decapentaplegic homolog 4 (Small) Mothers Against Decapentaplegic protein, Smad 4 protein, SMAD4, Mothers against decapentaplegic homolog 4 protein, Medea protein, MAD homolog 4 protein, DPC 4 protein, MADH4 protein, SMAD-4, Deleted in pancreatic carcinoma locus 4 protein, Med protein, Deleted in Pancreatic Carcinoma protein, SMAD-4 protein, MADH 4 protein, DPC4 protein, SMAD 4, MAD mothers against decapentaplegic Drosophila homolog 4 protein, MAD mothers against decapentaplegic homolog 4 protein, hSMAD4 protein, SMAD family member 4 protein, JIP protein, Deletion target in pancreatic carcinoma 4 protein, OTTHUMP00000163548 protein, Mothers against DPP homolog 4 protein, SMAD4 protein, SMAD 4 protein|
SDS-PAGE analysis of SMAD4 protein (His tag) (80R-1096)
SDS-PAGE gel analysis of SMAD4 protein (His tag) where the figure is annotated with amount of protein run on the gel.
|Residues||1-552 amino acids: MGSSHHHHHH SSGLVPRGSH MDNMSITNTP TSNDACLSIV HSLMCHRQGG ESETFAKRAI ESLVKKLKEK KDELDSLITA ITTNGAHPSK CVTIQRTLDG RLQVAGRKGF PHVIYARLWR WPDLHKNELK HVKYCQYAFD LKCDSVCVNP YHYERVVSPG IDLSGLTLQS NAPSSMMVKD EYVHDFEGQP SLSTEGHSIQ TIQHPPSNRA STETYSTPAL LAPSESNATS TANFPNIPVA STSQPASILG GSHSEGLLQI ASGPQPGQQQ NGFTGQPATY HHNSTTTWTG SRTAPYTPNL PHHQNGHLQH HPPMPPHPGH YWPVHNELAF QPPISNHPAP EYWCSIAYFE MDVQVGETFK VPSSCPIVTV DGYVDPSGGD RFCLGQLSNV HRTEAIERAR LHIGKGVQLE CKGEGDVWVR CLSDHAVFVQ SYYLDREAGR APGDAVHKIY PSAYIKVFDL RQCHRQMQQQ AATAQAAAAA QAAAVAGNIP GPGSVGGIAP AISLSAAAGI GVDDLRRLCI LRMSFVKGWG PDYPRQSIKE TPCWIEIHLH RALQLLDEVL HTMPIADPQP LD|
|Grade & Purity||> 90% pure|
|Molecular Weight||62.6 kDa (572 aa)|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||SMAD4 belongs to the SMAD family of proteins that mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD4 promotes the binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides the function of activation required for SMAD1 or SMAD2 to stimulate transcription and may also act as a tumor suppressor. Recombinant SMAD4 protein was expressed in E. coli and purified by using conventional chromatography techniques.|
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