snRNP A protein (30R-2124)
Purified recombinant snRNP A protein
Overview
Overview
| Synonyms | snRNP A, Small nuclear ribonucleoprotein A |
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| Protein Type | Recombinant |
| Applications | User optimized |
Specifications
| Expression System | HeLa cells |
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| Molecular Weight | 34 kDa |
| Form & Buffer | Supplied in lyophilized form with 25 mM Tris, 190 mM glycine, 0.025% (w/v) SDS, pH 8.4 |
| Concentration | 0.1 mg/ml |
Storage & Safety
| Storage | Store at 2-8 deg C in lyophilized form. Following reconstitution aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | snRNPs are RNA-protein complexes that combine with unmodified pre-mRNA and various other proteins to form a spliceosome, a large RNA-protein molecular complex upon which splicing of pre-mRNA occurs. The action of snRNPs is essential to the removal of introns from pre-mRNA, a critical aspect of post-transcriptional modification of RNA, occurring only in the nucleus of eukaryotic cells. The A protein is a target for anti-RNP sera. Autoimmune antibodiesagainst this protein are present in sera from patients with MCTD and with SLE |
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