SSA 52 kDa protein (30-1291)
Purified recombinant SSA 52 kDa protein
Overview
Overview
| Synonyms | 52 kDa Ro protein, 52 kDa ribonucleoprotein autoantigen Ro protein, SS-A protein, RING finger protein 81 protein, TRIM21 protein, Ro(SS-A) protein, Sjoegren syndrome type A protein, SS A protein, SS-A protein, SSA |
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| Species | Human |
| Protein Type | Recombinant |
| Applications | ELISA, Immunoassays, WB |
Specifications
| Expression System | E.coli |
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| Form & Buffer | Supplied in PBS buffer with 500 mM NaCl and 3M Urea |
Usage & Assay Information
| Usage Recommendations | To be optimized by the end user |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage, aliquot and freeze at -20 deg C for long term storage |
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General Information
| Biological Significance | SSA 52 kDa is an intracellular antibody effector in the intracellular antibody-mediated proteolysis pathway. It binds to immunoglobulin G as well as immunoglobulin M on antibody marked non-enveloped virions which have infected the cell. Either by autoubiquitination or by ubiquitination of a cofactor, it is then responsible for directing the virions to the proteasome. SSA 52 kDa itself is not degraded in the proteasome unlike both the viral capsid and the bound antibody. |
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