SSB protein (GST tag) (80-1376)
Purified recombinant SSB (La) protein (GST tag)
Overview
Overview
| Synonyms | Sjogren Syndrome Antigen B, SS-B protein, La protein, Sjogren Syndrome B protein, Autoantigen La |
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| Species | Human |
| Protein Type | Recombinant |
Specifications
| Residues | 1-408 aa |
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| Expression System | Baculovirus |
| Grade & Purity | > 85% pure |
| Method of Purification | Purified using proprietary chromatographic techniques |
| Molecular Weight | 77 kDa |
| Tag/Conjugate | GST tag |
| Form & Buffer | Supplied in 50mM Tris buffer, pH 8.0, 100mM NaCl, 1mM EDTA, 10% glycerol and 2mM DTT |
Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -70 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | SSB is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. |
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| Expression | SSB is expressed in the presence of proteins involved in DNA metabolism such as DnaG, HolC, PriA, PriB, RecO, RecQ and SbcB. Cellular localization is exclusively in the nucleus. |
| Implications in Disease | Defects in SSB expression have been linked to instances of Sjögren's syndrome, a chronic autoimmune disease in which the body's white blood cells destroy the exocrine glands, specifically the salivary and lacrimal glands, that produce saliva and tears, respectively. SSB antibodies are also detected during Hepatitis C infection. |
| Post-Translational Modifications | SSB is phosphorylated at the C-terminal part of the protein. Ubiquitination occurs at Lys9, Lys76, Lys95, Lys116, Lys176, Lys224, Lys229, Lys287, Lys312 and Lys328. |
| Database Links | Entrez Gene: 6741 Human, Omim: 109090 Human, SwissProt: P05455 Human, Unigene: 632535 Human |
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