ST2 antibody (10-2321)

Recombinant Fab monoclonal ST2 antibody

Synonyms Monoclonal ST2 antibody, Anti-ST2 antibody, Interleukin-1 receptor-like 1 antibody, Ly84 antibody, Lymphocyte antigen 84 antibody, Protein ST2 antibody, Protein T1 antibody, St2 antibody, St2-rs1 antibody, ST2L antibody, Ste2 antibody, T1 antibody, T1/ST2 antibody, DER4 antibody, Fit-1 antibody, Il1rl1 antibody, ILRL1 antibody, interleukin 1 receptor-like 1 antibody
Specificity Human
Protein Type Recombinant
Applications ELISA
Assay Information ST2 antibody pair: 10-2321 can be used as the capture antibody with 10-2319 as the detection antibody for detection of human ST2 in ELISA

Specifications

Host Mouse
Clone M72104
Isotype IgG1 kappa - Fab fragment
Expression System E.coli
Grade & Purity > 95% pure
Method of Purification ST2 antibodies screened using Phage Display system. Expressed in and purified from E. coli.
Tag/Conjugate His tag
Form & Buffer Supplied as liquid in 50 mM Potassium Phosphate, 10 mM Boric Acid, 150 mM NaCl, pH 7
Concentration > 1 mg/ml

Storage & Safety

Storage Store at -20 deg C in small aliquots. Avoid repeated freeze thawing.

General Information

Biological Significance ST2 is a receptor for IL33. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of ERK1 and/or ERK2, p38-alpha, and JNK1. Apparently promotes the activation and differentiation of T-helper 2 cells. ST2 antibody was produced as a recombinant Fab monoclonal antibody in a Phage Display system. This anti-ST2 antibody is used for detection of human ST2 in ELISA. The concentration of the antibody ranges from 1 mg/ml to 25 mg/ml depending on the lot. Recombinant Fab monoclonal antibodies have a number of advantages over standard antibodies including; improved scale up for batch consistency, more efficient binding so less antibody required, more accurate binding meaning fewer conjugation issues, less non specific due to removal of the Fc region, more flexibility for purification and labeling through a C-terminal His tag.

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