Staphylococcus Enterotoxin Type I antibody (10-7828)
Mouse monoclonal Staphylococcus Enterotoxin I antibody
Overview
Overview
| Synonyms | Monoclonal Enterotoxin I Staphylococcus Aureus antibody, Anti-Enterotoxin I Staphylococcus Aureus antibody, Staphylococcus Aureus I antibody, Enterotoxin I Staphylococcus Aureus antibody, Enterotoxin I Staphylococcus Aureus antibody, Enterotoxin I Staphylococcus Aureus antibody, Staphylococcus Aureus I antibody, Anti Enterotoxin I Staphylococcus Aureus antibody |
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| Specificity | Staphylococcus Enterotoxin B |
| Applications | ELISA, Immunoassays |
| Immunogen | Staphylococcus Enterotoxin I antibody was raised in mouse using recombinant St. aureus enterotoxin I expressed in E. coli as the immunogen |
| Assay Information | 10-7827 can be used in a sandwich immunoassay as a conjugate antibody in conjunction with 10-7828 as the coating antibody |
Specifications
| Host | Mouse |
|---|---|
| Clone | M18612EI2 |
| Isotype | IgG2a |
| Method of Purification | Staphylococcus Enterotoxin I antibody was purified by chromatography on protein G Sepharose. |
| Form & Buffer | Supplied in PBS, pH 7.4, 0.1 % NaN3. |
Storage & Safety
| Storage | Store at 4 deg C |
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General Information
| Biological Significance | Heat-labile enterotoxin is a type of labile toxin found in Escherichia coli that is inactivated at high temperatures. It acts similarly to the cholera toxin by raising cAMP levels through ADP-ribosylation of the alpha-subunit of a Gs protein leading to the constitutive activation of adenylate cyclase. Elevated cAMP levels stimulate secretion of Chloride ions and water from the enterocyte into the gut lumen, thus causing watery diarrhea. In addition to its effects on chloride secretion, which involve the same steps as the effects of cholera toxin, heat-labile enterotoxin binds additional substrates: lipopolysaccharide on the surface of E. coli cells and A-type blood antigens. The importance of these binding events is not yet known. |
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Staphylococcus Enterotoxin Type I antibody
Mouse monoclonal Staphylococcus Enterotoxin I antibody