Polyclonal STAT3 antibody, Anti-STAT3 antibody, STAT3, Signal transducer and activator of transcription 3 antibody, STAT-3, FLJ20882 antibody, STAT 3, STAT 3 antibody, APRF antibody, MGC16063 antibody, STAT-3 antibody
Applications
ICC, IHC-P, WB
Immunogen
STAT3 antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the C-terminal of human STAT3, identical to the related rat and Rabbit sequences, as the immunogen
Optimal conditions to be determined by the end user
Storage & Safety
Storage
Store at 4 deg C for short term storage. For long term storage aliquot and store at -20 deg C, avoid repeated freeze/thaw cycles.
General Information
Biological Significance
STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.