STAT5 antibody (70R-11850)

Rabbit polyclonal STAT5 antibody

Synonyms Polyclonal STAT5 antibody, anti-STAT5 antibody, STAT 5, STAT 5 antibody, STAT-5 antibody, STAT-5, Signal transducer and activator of transcription 5 antibody, STAT-5 antibody, STAT5, STAT 5 antibody, stat-5 antibody
Cross Reactivity Human, Mouse, Rat
Applications IHC, IP, WB
Immunogen STAT5 antibody was raised in Rabbit using synthetic peptide surrounding amino acid 777 of human Stat5 as the immunogen.
Assay Information STAT5 Blocking Peptide, catalog no. 33R-10776, is also available for use as a blocking control in assays to test for specificity of this STAT5 antibody

Images

Western Blot analysis using STAT5 antibody (70R-11850)

Western blot analysis of Stat5 expression in 3T3 cell lysate (Lane 1) and rat kidney tissue lysate (Lane 2).

Specifications

Host Rabbit
Isotype IgG
Method of Purification STAT5 antibody was purified by affinity chromatography
Form & Buffer Supplied in PBS buffer
Concentration 500 ug/ml

Usage & Assay Information

Usage Recommendations IP: 20 ug/ml, IHC: 20 ug/ml, WB: 2-10 ug/ml

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance Membrane receptor signaling by various ligands induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-alpha and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3beta appears to be activated by both while Stat3alpha is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 is activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.

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Images

  • <div><font face=Calibri size=2>Western Blot analysis using STAT5 antibody (70R-11850)</font></div>     | Western blot analysis of Stat5 expression in 3T3 cell lysate (Lane 1) and rat kidney tissue lysate (Lane 2).

Availability: In stock

Price: €274.03
Size: 100 ug
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