Streptolysin O protein (30R-3118)
Purified native Streptolysin O protein
Overview
Overview
| Synonyms | SLO protein |
|---|---|
| Species | Streptococcus hemolyticus |
| Protein Type | Native |
| Applications | ELISA, SDS-PAGE, WB |
Specifications
| Source | Streptococcus hemolyticus |
|---|---|
| Grade & Purity | > 95% pure |
| Form & Buffer | Supplied in liquid form in PBS buffer |
Storage & Safety
| Storage | Store at 4 deg C in a working aliquot for 1 week. For long term storage, aliquot and freeze at -20 to -80 deg C, avoid repeat freeze/thaw cycles |
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General Information
| Biological Significance | Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation. |
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