SURF1 protein (His tag) (80R-1238)
Purified recombinant Human SURF1 protein
|Synonyms||Surfeit locus protein 1 protein, SURF 1, SURF-1, , Surfeit 1 SURF 1 protein, SURF1, SURF 1 protein, SURF1 protein, SURF-1 protein, protein|
Coomassie Blue stained SDS-PAGE of SURF1 protein (His tag) (80R-1238)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||80-273 amino acids: MGSSHHHHHH SSGLVPRGSH MQVQRRKWKL NLIAELESRV LAEPVPLPAD PMELKNLEYR PVKVRGCFDH SKELYMMPRT MVDPVREARE GGLISSSTQS GAYVVTPFHC TDLGVTILVN RGFVPRKKVN PETRQKGQIE GEVDLIGMVR LTETRQPFVP ENNPERNHWH YRDLEAMARI TGAEPIFIDA NFQSTVPGGP IGGQTRVTLR NEHLQ|
|Grade & Purity||> 95% pure|
|Molecular Weight||24.3 kDa (215aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol, 1mM DTT and 0.1M NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||SURF1, also known as surfeit 1, is a member of the SURF1 family, which includes the related yeast protein SHY1 and rickettsial protein RP733. This protein is localized to the inner mitochondrial membrane and thought to be involved in the biogenesis of the cytochrome c oxidase complex. Defect in SURF1 is a cause of Leigh syndrome, a severe neurological disorder that is commonly associated with systemic cytochrome c oxidase deficiency. Recombinant SURF1 protein was expressed in E. coli and purified by using conventional chromatography techniques.|
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