Synphilin 1 antibody (20R-SG002)

Goat polyclonal Synphilin 1 antibody

Synonyms Polyclonal Synphilin 1 antibody, Anti-Synphilin 1 antibody, Synphilin-1 antibody, Synphilin 1, Synphilin 1, Synphilin -1, Synphilin -1 antibody, Synphilin 1 antibody
Cross Reactivity To be determined by end-user
Applications ELISA, IHC, WB
Immunogen Synphilin 1 antibody was raised in goat using a peptide; SLELNGEKDKDKGRTLQRT, as the immunogen.

Specifications

Host Goat
Form & Buffer Supplied as liquid whole serum without preservative

Usage & Assay Information

Usage Recommendations ELISA: >1:10,655, IHC-P: >1:400, WB: >1:2,000

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance Synphilin-1 is a cytoplasmic protein that is enriched in the neurophil of normal human brain. Although the exact function of synphilin-1 is unknown, it may possibly have a role as a cytoskeletal protein based on the presence of ankyrin-like repeats and an ATP, GTP-binding domain. It has been shown to be novel is its ability to associate in vivo with a-synuclein to form cytoplasmic eosinophilic inclusions. Additionally, it has been observed to be present in Lewy bodies of Parkinson disease, which are composed of a-synuclein. Because synphilin-1 is not found in protein aggregates of Alzheimer?s disease, it appears to be specific for a-synuclein-containing lesions. Synphilin-1 may facilitate the aggregation of a-synuclein into Lewy bodies.

References
Add a Paper

Sorry, but there are no references currently for this product.

Reviews

You need to be logged in to write a review. Please login here

Sorry there are currently no reviews for this product

Availability: In stock

Price: €277.55
Size: 250 ul
OR
Shipping
View Our Distributors