TAGLN2 protein (His tag) (80R-1696)
Purified recombinant Human TAGLN2 protein
|Synonyms||HA1756 protein, KIAA0120, Transgelin-2 protein, TAGLN 2, TAGLN-2 protein, TAGLN-2, TAGLN2, TAGLN 2 protein|
Coomassie Blue stained SDS-PAGE of TAGLN2 protein (His tag) (80R-1696)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||13-199 amino acids: MGSSHHHHHH SSGLVPRGSH MEVQQKIEKQ YDADLEQILI QWITTQCRKD VGRPQPGREN FQNWLKDGTV LCELINALYP EGQAPVKKIQ ASTMAFKQME QISQFLQAAE RYGINTTDIF QTVDLWEGKN MACVQRTLMN LGGLAVARDD GLFSGDPNWF PKKSKENPRN FSDNQLQEGK NVIGLQMGTN RGASQAGMTG YGMPRQIL|
|Grade & Purity||> 90% pure|
|Molecular Weight||23.4 kDa (208aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol, 0.1M NaCl and 1mM DTT.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||TAGLN2, also known transgelin 2, is one of the earliest markers of differentiated smooth muscle. This protein contains a calponin like repeat and a calponin-homology (CH) domain. It is downregulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. It also binds actin, causing actin fibers to gel within minutes of binding. Binding of transgelin to actin occurs at a ratio of 1:6 actin monomers. Recombinant human TAGLN2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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