Polyclonal TAP antibody, Anti-TAP antibody, MEX67 antibody, TAP antibody, DKFZp667O0311 antibody, NXF1 antibody, tip associating protein antibody, nuclear RNA export factor 1 antibody, tip-associating protein antibody, tip-associated protein antibody, mRNA export factor TAP antibody
Cross Reactivity
Human, Mouse
Applications
ICC, IF, WB
Immunogen
TAP antibody was raised in rabbit using a recombinant fragment corresponding to a region within amino acids 449 and 619 of TAP
Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
General Information
Biological Significance
This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p.